Alloxan diabetes definition of alloxan diabetes by. This compound has a high affinity for water and therefore exists as the monohydrate. The hyperglycemia was confirmed after 72 hrs by the. Cytotoxic compound that causes oxidative base damage to nuclear dnaalloxan monohydrate is used as a precursor to prepare purple dye murexide. Alloxan is one of the common diabetogenic agents often used to assess the antidiabetic potential of both pure compounds and plant. Pdf incidence of type ii diabetes is rapidly increasing worldwide. Pdf glycemic homeostasis refers to glucose balance or control within circulation in living organisms. Protein glycation, the most important source of free radicals, is leaded. The extracts of berberis lycium and diabetes mellitus in alloxan monohydrate induced diabetic rats.
Alloxan which is chemically known as 5,5dihydroxyl pyrimidine2,4,6trione is an organic compound, a urea derivative, a carcinogen and cytotoxic glucose analog. Antidiabetic effect of sida cordata in alloxan induced diabetic rats. Sigmaaldrich offers a number of alloxan monohydrate products. Pdf the extracts of berberis lycium and diabetes mellitus in. The induction of diabetes was confirmed after the 5th day of alloxan treatment by. The compound has the molecular formulae, c 4 h 2 n 2 o 4 and a relative molecular mass of 142. Join researchers using high quality alloxan monohydrate. Please take a look at the following rg link and pdf attachment. It is also used in research models to induce diabetes and destroy beta cells. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Alloxan and streptozotocin are the most popular diabetogenic agents used for assessing the. Alloxaninduced diabetes, a common model for evaluating. There is no warranty of accuracy or completeness of. The mechanisms of alloxan and streptozotocininduced diabetes.
The mechanism of alloxan and streptozotocin action in b cells of the rat pancreas t. Briefly overnight starved mice were made diabetic with a freshly prepared dose of alloxan monohydrate in pyrogen free water. Alloxan monohydrate induces diabetes in animals, although streptozotocin. Hypoglycemic effect of aqueous extract of telfairia occidentalis leaf. Research article alloxan induced diabetes mellitus in. Alloxan or mesoxalylurea is an organic compound based on a pyrimidine heterocyclic skeleton. Alloxan monohydrate was used to induce diabetes mellitus. Further, it is a strong oxidizing agent and it forms a hemiacetal with its reduced reaction product dialuric acid. The rats were injected with alloxan monohydrate in saline 0. Szkudelski department of animal physiology and biochemistry, university of agriculture, poznan, poland received november 2, 2000 accepted march 20, 2001 summary alloxan and streptozotocin are widely used to induce experimental diabetes in animals.
After an overnight fast, the rats were injected single dose 125mgkg of freshly prepared 5% solution of alloxan monohydrate in 0. Alloxan c4h2n2o4 cid 5781 structure, chemical names, physical and. By using a single intraperitoneal dose of 120 mgkg of alloxan monohydrate dissolved in cold saline solution administered rapidly and prevented from direct sunlight so as to prevent degradation of. Fbg in alloxan induced diabetic rats in a doserelated fashion, and also, showed signif. Alloxaninduced diabetes, a common model for evaluating the. Diabetes induction was done by single intra peritoneal injection of alloxan monohydrate 150 mgkg in saline. The mechanism of alloxan and streptozotocin action in b. The other diabetogenic chemical is less toxic but comparatively expensive. Pdf dose optimization of alloxan for diabetes in albino mice.
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